![]() Similar results were identified for MAP2K3, while the link with APOB reflected the inverse relationship between methylation at this locus and BWP. Thus, compared with nonsmokers with a GSTM5 methylation level of >25% (median BWP: 54.7%), those who had smoked during pregnancy and whose GSTM5 methylation was 25% p = 0.013 OR: 14.2). Smoking during pregnancy modified the effect of methylation on BWP. Results: Increased cord methylation at CpGs in GSTM5 and MAP2K3 was associated with a reduced risk of having a birth weight below the 50th percentile (p = 0.010 odds ratio : 0.33 and p = 0.024 OR: 0.24, respectively) while higher methylation levels in APOB were associated with an increased risk (p = 0.023 OR: 2.56). Linear and logistic regression analyses were used to identify relationships between BWP and methylation levels in the context of other key factors. ![]() The effects of other potentially important factors maternal smoking, folate-related metabolite levels and genetic variation in the MTHFR gene, were examined. Materials & methods: Methylation status was examined in candidate CpGs in 129 cord blood samples using Pyrosequencingâ„¢. ![]() Our aims were to investigate associations with BWP in specific CpGs identified by the array analysis in a significantly larger cohort and investigate the effects of other relevant factors on this association. Our previous array data indicate that methylation in human cord blood at gene-specific CpGs is associated with birth weight percentile (BWP). Aim: Evidence suggests that folic acid intake affects birth weight and that these effects may be mediated via the fetal epigenome.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |